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Richard Pryor (Eddie Lenahan, Dr. Kevin Slattery), Rachel Ticotin (Rachel Atwood), Rubén Blades (Louis), Maria Cardinale (), Joe Mantegna (Arthur Chambers), Bob Dishy (Dr. Foster), Sylvia Miles (Nurse Maggie Lesser), Joe Dallesandro (Stucky), Randall 'Tex' Cobb (Box), Bob Saget (Dr. Joffe), Joseph Ragno (Palazzi), Jon Polito (Kline), Garrett Morris (Helicopter Junkie), Brian Tarantina (Tommy Pinto), Jude Ciccolella (Jack Kinney), Cigdem Onat (Dr. Hoffman), Lucius Houghton (Fido), Joe Aufiery (Prosecutor), Kate McGregor-Stewart (Nurse Mary), Randell Haynes (Jackson), Al White (Reggie), Marquerita Wallace (Sexy Patient), Manera Smith (Pregnant Woman), Verna Hampton (Maternity Nurse), Lou Walker (Patient with Leg Cast), Doris Dworsky (Constipated Lady), Denis Hamill (Maintenance Man), John Hamill (Maintenance Man), Ralf D. Bode (Judge), Ann Pollack (Court Reporter), Miriam Cruz (Hispanic Woman), Teresa Yenque (Hispanic Woman), Wesley Snipes (Ambulance Driver), Mike Silver (Psycho Patient), Kevin Campbell (Psycho Patient), Mel Shrawder (Psycho Patient), Larry Graves (Psycho Patient), Jack Hallett (Psycho Nurse), Michael Medeiros (Junkie), Keith Roberts (Junkie), Karen Jones-Meadows (E.R. Nurse), Feiga Martinez (E.R. Nurse), Elizabeth Arlen (E.R. Nurse), Peg Banesse (E.R. Nurse), Joe Rivers (E.R. Orderly), Clifford Jackson (E.R. Maintenance), Lara Marshall (E.R. Clerk), Leroy Staples (Body Guard), Johnny Howie (Body Guard), Steve Boles (Guard), John Woodson (Guard), Bennie Moore (Guard (as Ben Moore)), Jeffrey Pillars (Correction Officer), Joseph Coscia (Prison Guard), Del Roy (Porno Shop Cop), Laura Bastianelli (Porno Shop Cop), Lee Lawrence (Porno Shop Cop), Geoff Gordon (Porno Shop Cop), Ron Amari (Fat Patient), Raymond Rosario (Boy in Waiting Room)
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